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    Graphene oxide reinforced doped dicalcium phosphate bone cements for bone tissue regenerations
    (Springer, 2022) Motameni, Ali; Alshemary, Ammar Z.; Dalgic, Ali Deniz; Keskin, Dilek; Evis, Zafer
    Artificial bone cements have widespread applications in orthopedic and dental surgeries. Nevertheless, there is a need to develop novel materials for artificial bone cements due to limitations like short-service life, weak interaction and attachment with living hard tissue, and the inability to facilitate bone regeneration of calcified tissues rather than replacing them. In the present research, a novel combination of lanthanum (La3+) ions doped dicalcium phosphate (DCP) (La-DCP) and 1.5-3.5 wt.% of graphene oxide (GO) doped La-DCP bone cement materials were successfully synthesized and reported for the first time. Acid/base interaction between La-beta-tricalcium phosphate (La-beta TCP) and monocalcium phosphate monohydrate (MCPM) in the presence of water was the basis for making the La-DCP cements. The synthesized cements were characterized using the XRD, FTIR, FESEM, UV-Vis and TGA techniques. Produced material had La-DCP as in the monetite phase, and La-DCP particles were formed in agglomerates of irregular shapes. The presence of GO enhanced the growth rate of monetite particles, significantly decreased the setting time of the La-DCP bone cement, enhanced mechanical properties and enhanced the adsorption capacity of La-DCP. In vitro studies showed that synthesized GO/La-DCP bone cements were biocompatible, and the proliferation and differentiation properties of human osteosarcoma (Saos-2) cells were significantly improved with the addition of GO. In summary, the synthesized GO/La-DCP bone cement materials, which exhibit good biocompatibility and mechanical properties, have the potential to be employed in bone defect healing.
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    Mechanical and biological evaluation of ?-dicalcium silicate/dicalcium phosphate-based cements: promising materials for biomedical applications
    (Taylor & Francis Ltd, 2025) Alshemary, Ammar Z.; Marandi, Almataz Bellah; Ali, Daver; Kose, Tugba; Dalgic, Ali Deniz; Motameni, Ali; Evis, Zafer
    This study explores the synthesis and evaluation of beta-Dicalcium silicate and Dicalcium phosphate-based cements for biomedical use. beta-Tricalcium phosphate was synthesized using microwave-assisted wet precipitation, while beta-Dicalcium silicate was prepared via the sol-gel method. Composites with varying beta-Dicalcium silicate contents (20%, 30%, 40%) were formulated and characterized using X-ray diffraction, Fourier-transform infrared spectroscopy, and Field emission scanning electron microscope analyses. The 40% beta-Dicalcium silicate composite showed the highest compressive strength at 10.22 MPa. Antibacterial tests against Staphylococcus aureus revealed that gentamicin-loaded Dicalcium phosphate cement had superior properties. Cytotoxicity studies using the Osteogenic sarcoma cell line revealed that the beta-Dicalcium Silicate /Dicalcium Phosphate composites supported better cell viability compared to pure Dicalcium phosphate cement, with the 20% beta-Dicalcium silicate /Dicalcium phosphate composition being the most effective in promoting cell growth. These findings suggest that beta-Dicalcium silicate /Dicalcium phosphate composites hold promise for biomedical applications.