Therapeutic effectiveness of low-calorie ketogenic diet on body composition and biochemical parameters in polycystic ovary syndrome - An intervention study

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dc.authorid0000-0002-0659-3586
dc.contributor.authorAvuk, Hande Seven
dc.contributor.authorBad, Murat
dc.date.accessioned2026-04-04T18:56:04Z
dc.date.available2026-04-04T18:56:04Z
dc.date.issued2025
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractIntroduction: the effectiveness of the ketogenic diet (KD) as a therapeutic approach for managing weight, hormonal, and metabolic aspects of polycystic ovary syndrome (PCOS) requires further clarification despite its growing popularity. Objectives: this study evaluated the short-term effects of a 4-week low-calorie ketogenic diet (LCKD) on body composition, biochemical, and hormonal parameters in overweight or obese women with PCOS. Methods: thirteen women with PCOS (mean age 29.77 +/- 7.54 years, median BMI 27.2 kg/m2) participated in this clinical intervention study. Body composition (bio-electrical impedance), anthropometric measurements, and biochemical/hormonal parameters were assessed pre-and post-intervention. Results: participants achieved a mean body weight loss of 6.90 % +/- 2.04 %. Significant reductions were observed in body weight, BMI, fat percentage, fat mass, fat-free mass, waist, hip, and neck circumferences, and waist-to-hip/waist-to-height ratios (p < 0.05). LCKD also led to significant decreases in fasting glucose, insulin, HOMA-IR, HDL-cholesterol, prolactin, and IGF-1 levels (p < 0.05). Conversely, sexual hormon binding globulin (SBHG) and TNF-alpha levels significantly increased (p < 0.05). Multiple regression analysis indicated that changes in waist (t = 4.196), hip (t = 3.983), and neck (t =-2.820) circumferences significantly impacted prolactin levels, while changes in fat percentage (t =-3.326, p = 0.021), fat mass (t = 3.501, p = 0.017), and hip circumference (t = 2.905, p = 0.034) influenced SHBG levels (p < 0.05). Conclusions: short-term LCKD intervention shows potential as a therapeutic dietary strategy, yielding beneficial effects on both anthropometric and key biochemical parameters in overweight or obese women with PCOS.
dc.identifier.doi10.20960/nh.05901
dc.identifier.doi10.20960/nh.05901
dc.identifier.endpage941
dc.identifier.issn0212-1611
dc.identifier.issn1699-5198
dc.identifier.issue5
dc.identifier.pmid41021353
dc.identifier.scopus2-s2.0-105021344828
dc.identifier.scopusqualityQ3
dc.identifier.startpage932
dc.identifier.urihttps://doi.org/10.20960/nh.05901
dc.identifier.urihttps://hdl.handle.net/11411/10669
dc.identifier.volume42
dc.identifier.wosWOS:001694225100010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAran Ediciones, S L
dc.relation.ispartofNutricion Hospitalaria
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectKetogenic Diet
dc.subjectMenstrual Dysfunction
dc.subjectPolycystic Ovary Syndrome
dc.subjectVery Low-Calorie Ketogenic Diet
dc.subjectMedical Nutrition Therapy
dc.titleTherapeutic effectiveness of low-calorie ketogenic diet on body composition and biochemical parameters in polycystic ovary syndrome - An intervention study
dc.typeArticle

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