The Effect of a Chronobiological Feeding Model on Growth Parameters and Length of Hospitalization in Preterm Infants: A Randomized Controlled Study

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dc.authorid0000-0002-4797-2427
dc.contributor.authorTemizsoy, Ebru
dc.contributor.authorUysal, Guelzade
dc.contributor.authorKaradag, Nilguen
dc.date.accessioned2026-04-04T18:55:48Z
dc.date.available2026-04-04T18:55:48Z
dc.date.issued2025
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractBackground and Purpose: Preterm infants are born before the 37th gestational week and need prompt nutrition. The circadian rhythm is an internal 24-hour cycle regulated by endogenous molecules. Human milk contains different biological peptides at different times within this cycle. Chrononutrition is a feeding model that is adjusted to match the biological clock of the individual. This study tests chrononutrition as a superior feeding model in preterm infants. This study aimed to evaluate the effect of the chronobiological feeding model on growth parameters and discharge time among preterm infants. Methods: We conducted a prospective, randomized controlled trial in a tertiary neonatal intensive care unit between October 2021 and March 2022, randomized preterm infants to receive either chrononutrition (study group = 45) or standard feeding (control group = 46), and used the infant's follow-up form for data collection. Results: Among 91 neonates, the median gestational age was 33 weeks, and the mean birth weight was 2,100 g. Demographic findings and growth parameters showed no difference between the groups (p > 0.05). Weight gain and percentile measurements at discharge were statistically significantly higher in the study group (p = 0.002 and p = 0.003, respectively). Discharge time was statistically significantly lower after full enteral feeding and hospitalization time was shorter in the study group (p = 0.001). Conclusions: The chronobiological feeding model showcased significant positive effects on anthropometrics and percentile measurements at discharge and led to a 2-day reduction in the length of hospital stay.
dc.description.sponsorshipInstitute of Graduate Studies, Pediatric Nursing Department
dc.description.sponsorshipThe authors would like to thank the nursing staff and the doctors for their help, as well as the newborn infants and their parents for contributing to this article. This study is completed as a Doctorate Thesis at Istanbul Okan University, Institute of Graduate Studies, Pediatric Nursing Department.
dc.identifier.doi10.1089/bfm.2024.0221
dc.identifier.doi10.1089/bfm.2024.0221
dc.identifier.endpage440
dc.identifier.issn1556-8253
dc.identifier.issn1556-8342
dc.identifier.issue6
dc.identifier.pmid40195944
dc.identifier.scopus2-s2.0-105002405549
dc.identifier.scopusqualityQ1
dc.identifier.startpage432
dc.identifier.urihttps://doi.org/10.1089/bfm.2024.0221
dc.identifier.urihttps://hdl.handle.net/11411/10555
dc.identifier.volume20
dc.identifier.wosWOS:001461971300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofBreastfeeding Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectChrononutrition
dc.subjectCircadian Rhythm
dc.subjectPreterm
dc.subjectUndernutrition
dc.subjectFeeding Model
dc.titleThe Effect of a Chronobiological Feeding Model on Growth Parameters and Length of Hospitalization in Preterm Infants: A Randomized Controlled Study
dc.typeArticle

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