3D Modeling of Self-Expandable Valves for PPVI in Distinct RVOT Morphologies

Basit Öğe Kaydı
dc.authorid0000-0003-1041-6299
dc.contributor.authorOdemis, Ender
dc.contributor.authorAka, Ibrahim Basar
dc.contributor.authorKizilkaya, Mete Han
dc.date.accessioned2026-04-04T18:55:21Z
dc.date.available2026-04-04T18:55:21Z
dc.date.issued2026
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractTetralogy of Fallot often requires transannular patch repair, leading to pulmonary insufficiency. Percutaneous pulmonary valve implantation (PPVI) with self-expandable valves offers a promising alternative, especially for enlarged right ventricular Queryoutflow tracts (RVOT). Five RVOT types identified in patients with Tetralogy of Fallot reflect anatomical variations due to disease and prior surgeries. This study assesses the Pulsta THV (R) valve's in vitro hemodynamic performance across these RVOT morphologies using 3D-printed models. Five RVOT morphologies were recreated as 3D models from patient-specific imaging data. The Pulsta THV (R) valves, available in 28, 30, and 32 mm sizes, were evaluated using the ViVitro Pulse Duplicator System at three cardiac outputs (2, 3.5, and 5 L/min). Hemodynamic performance was assessed by measuring regurgitation rates and pressure gradients in the left and right pulmonary arteries. The Pulsta THV (R) performed optimally in RVOT Types 1 and 2, demonstrating lower regurgitation rates and pressure gradients, particularly with larger valve sizes. Conversely, RVOT Types 3 and 5 showed increased pressure gradients and hemodynamic variability, indicating less favorable outcomes. The results highlighted the critical role of precise anatomical compatibility, with larger valve sizes proving more effective in enlarged RVOT geometry. Valve sizes tailored to specific RVOT morphologies can enhance PPVI outcomes. Types 1 and 2 are ideal for PPVI, while Types 3 and 5 present challenges due to hemodynamic variability. This study supports 3D modeling and in vitro testing for pre-procedural planning to reduce complications, with future research exploring dynamic imaging and materials mimicking tissue properties.
dc.description.sponsorshipKo niversitesi Translasyonel Timath;p Arascedil;timath;rma Merkezi
dc.description.sponsorshipThe authors would like to thank Mhd Homam Alhaj Ali for his assistance in data collection.
dc.identifier.doi10.1007/s00246-025-03796-7
dc.identifier.doi10.1007/s00246-025-03796-7
dc.identifier.endpage551
dc.identifier.issn0172-0643
dc.identifier.issn1432-1971
dc.identifier.issue2
dc.identifier.pmid39923207
dc.identifier.scopus2-s2.0-85217686799
dc.identifier.scopusqualityQ2
dc.identifier.startpage542
dc.identifier.urihttps://doi.org/10.1007/s00246-025-03796-7
dc.identifier.urihttps://hdl.handle.net/11411/10382
dc.identifier.volume47
dc.identifier.wosWOS:001416012100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPediatric Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectPercutaneous Pulmonary Valve Implantation
dc.subjectRight Ventricular Outflow Tract
dc.subject3D Printing
dc.subjectPulsta Thv (R)
dc.subjectTetralogy Of Fallot
dc.subjectSelf-Expandable Valves
dc.subjectMock Circulatory System
dc.title3D Modeling of Self-Expandable Valves for PPVI in Distinct RVOT Morphologies
dc.typeArticle

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