Injectable Liposome-Loaded Hydrogel Formulations with Controlled Release of Curcumin and ?-Tocopherol for Dental Tissue Engineering

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dc.authorid0000-0002-6581-5126
dc.authorid0000-0003-2904-1204
dc.authorid0000-0003-3250-4193
dc.authorid0000-0003-4755-189X
dc.authorid0000-0001-7438-9627
dc.authorid0000-0001-9359-0131
dc.authorid0000-0003-1777-9295
dc.contributor.authorAtila, Deniz
dc.contributor.authorDalgic, Ali Deniz
dc.contributor.authorKrzeminska, Agnieszka
dc.contributor.authorPietrasik, Joanna
dc.contributor.authorGendaszewska-Darmach, Edyta
dc.contributor.authorBociaga, Dorota
dc.contributor.authorKumaravel, Vignesh
dc.date.accessioned2026-04-04T18:55:18Z
dc.date.available2026-04-04T18:55:18Z
dc.date.issued2024
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractAn injectable hydrogel formulation is developed utilizing low- and high-molecular-weight chitosan (LCH and HCH) incorporated with curcumin and alpha-tocopherol-loaded liposomes (Lip/Cur+Toc). Cur and Toc releases are delayed within the hydrogels. The injectability of hydrogels is proved via rheological analyses. In vitro studies are conducted using human dental pulp stem cells (hDPSCs) and human gingival fibroblasts (hGFs) to examine the biological performance of the hydrogels toward endodontics and periodontics, respectively. The viability of hDPSCs treated with the hydrogels with Lip/Cur+Toc is the highest till day 14, compared to the neat hydrogels. During odontogenic differentiation tests, alkaline phosphatase (ALP) enzyme activity of hDPSCs is induced in the Cur-containing groups. Biomineralization is enhanced mostly with Lip/Cur+Toc incorporation. The viability of hGFs is the highest in HCH combined with Lip/Cur+Toc while wound healing occurs almost 100% in both (Lip/Cur+Toc@LCH and Lip/Cur+Toc@HCH) after 2 days. Antioxidant activity of Lip/Cur+Toc@LCH on hGFs is significantly the highest among the groups. Antimicrobial tests demonstrate that Lip/Cur+Toc@LCH is more effective against Escherichia coli whereas so is Lip/Cur+Toc@HCH against Staphylococcus aureus. The antimicrobial mechanism of the hydrogels is investigated for the first time through various computational models. LCH and HCH loaded with Lip/Cur+Toc are promising candidates with multi-functional features for endodontics and periodontics.
dc.description.sponsorshipInternational Research Agendas PLUS programme of the Foundation for Polish Science (FNP), co-financed by the European Union under the European Regional Development Found; International Research Agendas PLUS programme of the Foundation for Polish Science [MAB PLUS/2019/11]; European Union under the European Regional Development Found
dc.description.sponsorshipThis research was conducted as a part of the International Research Agendas PLUS programme of the Foundation for Polish Science, co-financed by the European Union under the European Regional Development Found (MAB PLUS/2019/11). All computations were carried out using computational resources of the Blue-ocean cluster, Lodz University of Technology.
dc.identifier.doi10.1002/adhm.202400966
dc.identifier.doi10.1002/adhm.202400966
dc.identifier.issn2192-2640
dc.identifier.issn2192-2659
dc.identifier.issue23
dc.identifier.pmid38847504
dc.identifier.scopus2-s2.0-85196181874
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/adhm.202400966
dc.identifier.urihttps://hdl.handle.net/11411/10350
dc.identifier.volume13
dc.identifier.wosWOS:001249583300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAdvanced Healthcare Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectAntimicrobial
dc.subjectBioactive Agents
dc.subjectBiopolymers
dc.subjectDental Infections
dc.subjectDft (Density Functional Theory)
dc.titleInjectable Liposome-Loaded Hydrogel Formulations with Controlled Release of Curcumin and ?-Tocopherol for Dental Tissue Engineering
dc.typeArticle

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