Mechanical and biological evaluation of ?-dicalcium silicate/dicalcium phosphate-based cements: promising materials for biomedical applications

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dc.authorid0000-0003-2904-1204
dc.authorid0000-0002-8500-7820
dc.authorid0000-0002-7518-8162
dc.authorid0000-0001-9226-6444
dc.contributor.authorAlshemary, Ammar Z.
dc.contributor.authorMarandi, Almataz Bellah
dc.contributor.authorAli, Daver
dc.contributor.authorKose, Tugba
dc.contributor.authorDalgic, Ali Deniz
dc.contributor.authorMotameni, Ali
dc.contributor.authorEvis, Zafer
dc.date.accessioned2026-04-04T18:55:43Z
dc.date.available2026-04-04T18:55:43Z
dc.date.issued2025
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractThis study explores the synthesis and evaluation of beta-Dicalcium silicate and Dicalcium phosphate-based cements for biomedical use. beta-Tricalcium phosphate was synthesized using microwave-assisted wet precipitation, while beta-Dicalcium silicate was prepared via the sol-gel method. Composites with varying beta-Dicalcium silicate contents (20%, 30%, 40%) were formulated and characterized using X-ray diffraction, Fourier-transform infrared spectroscopy, and Field emission scanning electron microscope analyses. The 40% beta-Dicalcium silicate composite showed the highest compressive strength at 10.22 MPa. Antibacterial tests against Staphylococcus aureus revealed that gentamicin-loaded Dicalcium phosphate cement had superior properties. Cytotoxicity studies using the Osteogenic sarcoma cell line revealed that the beta-Dicalcium Silicate /Dicalcium Phosphate composites supported better cell viability compared to pure Dicalcium phosphate cement, with the 20% beta-Dicalcium silicate /Dicalcium phosphate composition being the most effective in promoting cell growth. These findings suggest that beta-Dicalcium silicate /Dicalcium phosphate composites hold promise for biomedical applications.
dc.identifier.doi10.1080/16583655.2025.2461817
dc.identifier.doi10.1080/16583655.2025.2461817
dc.identifier.issn1658-3655
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85217374252
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/16583655.2025.2461817
dc.identifier.urihttps://hdl.handle.net/11411/10536
dc.identifier.volume19
dc.identifier.wosWOS:001415485500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Taibah University for Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectBiocements
dc.subjectDicalcium Phosphate
dc.subjectBeta-Dicalcium Silicate
dc.subjectAntibacterial Activity
dc.subjectCompressive Strength
dc.subjectCytotoxicity
dc.titleMechanical and biological evaluation of ?-dicalcium silicate/dicalcium phosphate-based cements: promising materials for biomedical applications
dc.typeArticle

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