Cell reprogramming. Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming

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dc.authorid0000-0002-9253-8152en_US
dc.contributor.authorOtu, Hasan
dc.date.accessioned2021-03-15T09:27:03Z
dc.date.available2021-03-15T09:27:03Z
dc.date.issued2014-08-15
dc.description.abstractUnfertilized oocytes have the intrinsic capacity to remodel sperm and the nuclei of somatic cells. The discoveries that cells can change their phenotype from differentiated to embryonic state using oocytes or specific transcription factors have been recognized as two major breakthroughs in the biomedical field. Here, we show that ASF1A, a histone-remodeling chaperone specifically enriched in the metaphase II human oocyte, is necessary for reprogramming of human adult dermal fibroblasts (hADFs) into undifferentiated induced pluripotent stem cell. We also show that overexpression of just ASF1A and OCT4 in hADFs exposed to the oocyte-specific paracrine growth factor GDF9 can reprogram hADFs into pluripotent cells. Our Report underscores the importance of studying the unfertilized MII oocyte as a means to understand the molecular pathways governing somatic cell reprogramming.en_US
dc.fullTextLevelFull Texten_US
dc.identifier.doi10.1126/science.1254745
dc.identifier.issn1095-9203
dc.identifier.issn0036-8075
dc.identifier.pmid25035411en_US
dc.identifier.scopus2-s2.0-84906266342en_US
dc.identifier.urihttps://hdl.handle.net/11411/3404
dc.identifier.urihttps://doi.org/10.1126/science.1254745
dc.identifier.wosWOS:000340593100047en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.issue6198en_US
dc.language.isoenen_US
dc.nationalInternationalen_US
dc.numberofauthors4en_US
dc.pages822-825en_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.relation.ispartofScienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCell reprogramming. Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming
dc.typeArticle
dc.volume345en_US

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