Novel small-sized ePTFE valves for neonatal RVOT reconstruction: an in-vitro investigation

Basit Öğe Kaydı
dc.authorid0000-0001-7637-4445
dc.contributor.authorAka, Ibrahim Basar
dc.contributor.authorAltin, Husnu Firat
dc.contributor.authorAka, Bahaeddin Umur
dc.contributor.authorTurkoz, Riza
dc.contributor.authorPekkan, Kerem
dc.date.accessioned2026-04-04T18:55:34Z
dc.date.available2026-04-04T18:55:34Z
dc.date.issued2025
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractSmall-sized right ventricle to pulmonary artery conduits are hindered by calcification, degeneration, or infective endocarditis and face limited availability. Valved conduits of expanded polytetrafluoroethylene leaflets offer a promising path toward enhanced longevity and performance. This in-vitro study introduces innovative expanded polytetrafluoroethylene valve designs for small-sized conduits.Three bicuspid and three tricuspid expanded polytetrafluoroethylene leaflets designed for size 12 mm were tested using an in-vitro pediatric right-heart mockup loop and compared with our baseline leaflet design. Polyvinylchloride was used to create a transparent tube for visual access. Regurgitation rates, pressure gradients, effective orifice area under 0.5-3 L/min cardiac outputs, and 100-150beats/min heart rates are measured. Mechanical differences between expanded polytetrafluoroethylene and polyvinylchloride are investigated through biaxial strain tests. In newborn hemodynamic conditions, 0.5-1 L/min cardiac output, bileaflet valves demonstrated regurgitation rates below 20%, and two tricuspid models maintained regurgitation rates below 15% with gradients below 25 mmHg. In infant conditions, 1-3 L/min output, the regurgitation rates of trileaflet models were below 20%, with gradients consistently below 35 mmHg. The fully coapting bileaflet model showed a regurgitation rate of less than 15% and a gradient below 30 mmHg across newborn and infant conditions. A circumferential difference of less than 0.12 mm was detected between expanded polytetrafluoroethylene and polyvinylchloride. Both the fully coapting bileaflet and redundant trileaflet configurations can be integrated in the small conduits. Polyvinylchloride can be an alternative to expanded polytetrafluoroethylene tube graft in in-vitro studies, allowing visual access to assess leaflet kinematics.
dc.description.sponsorshipEuropean Research COncuil (ERC) Proof of COncept [999765]
dc.description.sponsorshipFunding was provided by the European Research COncuil (ERC) Proof of COncept #999765 BloodTurbine.
dc.identifier.doi10.1016/j.jbiomech.2025.112613
dc.identifier.doi10.1016/j.jbiomech.2025.112613
dc.identifier.issn0021-9290
dc.identifier.issn1873-2380
dc.identifier.pmid40064129
dc.identifier.scopus2-s2.0-86000279303
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jbiomech.2025.112613
dc.identifier.urihttps://hdl.handle.net/11411/10454
dc.identifier.volume183
dc.identifier.wosWOS:001444314200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofJournal of Biomechanics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectRight Ventricular Outflow Tract
dc.subjectValve Hemodynamics
dc.subjectPulmonary Valve
dc.subjectValved Conduit
dc.subjectEptfe
dc.titleNovel small-sized ePTFE valves for neonatal RVOT reconstruction: an in-vitro investigation
dc.typeArticle

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