Development of PCL/PVA/PCL scaffold for local delivery of calcium fructoborate for bone tissue engineering

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dc.contributor.authorDalgic, Ali Deniz
dc.date.accessioned2026-04-04T18:48:31Z
dc.date.available2026-04-04T18:48:31Z
dc.date.issued2024
dc.description.abstractCalcium fructoborate (CaFB) has gathered attention due to its boron and calcium content, both of which are known to support bone health, deposition and regeneration. Previous studies have shown that CaFB has a positive effect on bone health and has been proven to promote bone-like properties. In light of this information, a local CaFB delivering scaffold could improve bone regeneration in cases of bone tissue loss. This study aimed to design a layer-by-layer polymeric sponge capable of achieving controlled local delivery of CaFB to improve bone tissue healing. The dose-dependent effect of CaFB on the cell viability of the Saos-2 cell line was investigated in vitro. Layer-by-layer structure of the polymeric scaffold supported controlled release of CaFB, with 33.9±7.4% released after 7 days of incubation. CaFB at 31.25 µg/mL concentration was able to improve Saos-2 cell viability up to 174.7±24.1% and 127.7±8.7% after 1 and 4 days of incubation. After 7 days of incubation CaFB treatment at concentrations of 250, 125, 62.5 and 31.25 µg/mL improved cell viability up to 194.3±47.7, 155.3±17.7, 149.4±5.4 and 132.5±13.3%. The polycaprolactone/polyvinyl alcohol/polycaprolactone (PCL/PVA/PCL) scaffold supported the viability of cells for 7 days and was shown to be biocompatible. The results of this study showed that CaFB is a potential compound that can be locally delivered within a scaffold system to improve bone tissue regeneration. © 2024, Turkish Energy, Nuclear and Mining Research Agency. All rights reserved.
dc.description.sponsorshipYildiz Teknik Üniversitesi; BİTUAM
dc.identifier.doi10.30728/boron.1549809
dc.identifier.endpage152
dc.identifier.issn2149-9020
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85214441414
dc.identifier.scopusqualityQ4
dc.identifier.startpage143
dc.identifier.trdizinid1294567
dc.identifier.urihttps://doi.org/10.30728/boron.1549809
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1294567
dc.identifier.urihttps://hdl.handle.net/11411/10196
dc.identifier.volume9
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkish Energy, Nuclear and Mining Research Agency
dc.relation.ispartofJournal of Boron
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260402
dc.subjectBone Tissue Engineering
dc.subjectBoron
dc.subjectCalcium Fructoborate
dc.subjectPolycaprolactone
dc.subjectPolyvinyl Alcohol
dc.titleDevelopment of PCL/PVA/PCL scaffold for local delivery of calcium fructoborate for bone tissue engineering
dc.typeArticle

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